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Toxicokinetics Nicotine, a weak base alkaloid (pKa = 8.5), is poorly absorbed from the stomach because it is ionised in the acidic gastric fluid, but is well absorbed in the small intestine, which has an alkaline pH and a large surface area 10 , 11

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This is concerning, as severe sunburn increases the risk of developing all three types of skin cancer (up to two and a half times for melanoma), compared to no history of severe sunburn (266)